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COVID-19 deaths in the U.S. have tumbled to an average of around 600 per day — the lowest level in 10 months — with the number of lives lost dropping to single digits in well over half the states and hitting zero on some days.

Confirmed infections have fallen to about 38,000 per day on average, their lowest mark since mid-September. While that is still cause for concern, they have plummeted 85% from a peak of more than a quarter-million per day in early January.

The last time deaths were this low was early July, nearly a year ago. COVID-19 deaths in the U.S. topped out in mid-January at an average of more than 3,400 a day, just a month into the biggest vaccination drive in the nation's history.

The Boston Herald put a huge zero on Wednesday's front page under the headline “First time in nearly a year state has no new coronavirus deaths.” Indiana reported only one COVID-19 fatality Tuesday. Kansas, which peaked at 63 deaths on Dec. 22, has been in the single digits since February and has seen multiple days with just one fatality.

Dr. Amesh Adalja, an infectious disease specialist at Johns Hopkins University, said that vaccinations have played a crucial role even as the nation struggles to reach herd immunity.

“The primary objective is to deny this virus the ability to kill at the rate that it could, and that has been achieved," he said. “We have in in effect tamed the virus.”

About 45% of the nation's adults are fully vaccinated, and nearly 59% have received at least one dose, according to the Centers for Disease Control and Prevention. This week, Pfizer's vaccine won authorization for use in 12- to 15-year-olds, in a move that could make it easier to reopen the nation's schools.

Physicians like Dr. Tom Dean in South Dakota’s rural Jerauld County are cautiously optimistic, concerned about the many people who have decided against getting vaccinated or have grown lax in guarding against infections. The county has seen just three confirmed cases in the last two weeks, according to Johns Hopkins data.

“What I’m afraid of is people believing this whole thing is over and you don’t have to worry about it any more,” Dean said. “I think complacency is our biggest threat right now.”

Several states, including Wyoming, Vermont, Alaska and Hawaii, were averaging fewer than one death per day over the past week, according to data through Tuesday from Johns Hopkins.

And even among the five states with the highest daily deaths — Michigan with an average of 65.4, Florida with 61.7, California with 48, Texas with 44 and New York with 39.3 — all but Florida's number is going down.

California, the epicenter of the U.S. outbreak over the winter, logged 1,231 confirmed infections Wednesday, down from 40,000 at its peak. Los Angeles County reported 18 deaths Tuesday, versus more than 200 a day in January.

In Kansas, the Amos Family Funeral Home & Crematory was swamped with COVID-19 victims at the height of the outbreak, seeing several a week. But it has now been weeks since it has handled one, said Parker Amos, president of the Kansas City-area business.

“It is a huge relief,” he said. “Especially at the start of this, when we didn’t know exactly how bad this was or how bad this was going to get, it was scary being in this industry.”

The funeral home is now working through a backlog of memorial services that families put off when cases were surging.

“You want families to be able to have that closure," Amos said, “and to hold on to that for a year is something that we feel for those families in a big way because that is something that is really hard."

The encouraging outlook stands in sharp contrast to the catastrophe unfolding in places like India and Brazil.

The overall U.S. death toll stands at about 583,000, and teams of experts consulted by the CDC projected in a report last week that new deaths and cases will fall sharply by the end of July and continue dropping after that.

“I think we are in a great place, but I think India is an important cautionary tale," warned Justin Lessler, a professor of epidemiology at John Hopkins.

“If there is a right combination of vaccine hesitancy, potentially new variants and quickly rolling back control measures that comes together, we could potentially screw this up and have yet another wave that is completely unnecessary at this point."